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THE NUCLEUS: Mechanosensing in cardiac disease

6 Jul 2021

Abstract excerpt

The nucleus provides a physical and selective chemical boundary to segregate the genome from the cytoplasm. The contents of the nucleus are surrounded by the nuclear envelope, which acts as a hub of mechanosensation, transducing forces from the external cytoskeleton to the nucleus, thus impacting on nuclear morphology, genome organisation, gene transcription and signalling pathways. Muscle tissues such as the...

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PMID: 34242685
DOI: 10.1016/j.biocel.2021.106035

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