Article

T cells expressing multiple co-inhibitory molecules in acute malaria are not exhausted but exert a suppressive function

2021-04-20

Abstract excerpt

Overwhelming activation of T cells in acute malaria is associated with severe outcomes. Thus, counter-regulation by anti-inflammatory mechanisms is indispensable for an optimal resolution of disease. Using Plasmodium berghei ANKA (PbA) infection of C57BL/6 mice, we performed a comprehensive analysis of co-inhibitory molecules expressed on CD4 + and CD8 + T cells using an unbiased cluster analysis approach. We i...

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Literature Corpus work: 709d1c4f-1e7f-5a61-93d8-92ce7d481e4a
DOI: 10.1101/2021.04.19.440453

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