Phenotypic characterization of mucosal-associated invariant T cells in visceral leishmaniasis and HIV co-infection.

doi:10.3389/fimmu.2026.1882545

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Article

Phenotypic characterization of mucosal-associated invariant T cells in visceral leishmaniasis and HIV co-infection.

Frontiers in immunology - 1 Jan 2026

Pereira Victoria Hellena Silva, Nogueira Gustavo Augusto Fonseca, Borges-Fernandes Luana, de Carvalho Silvia Hees, Nogueira Adelina Machado de Carvalho, Araújo Argus Leão, Brito-de-Sousa Joaquim Pedro, Rodrigues Juliana Assunção, Toledo João Paulo Resende Magalhães, Magalhães Vanessa Caroline Randi, de Carvalho Jairo Campos, da Cunha Livia Fulgencio, Coelho-Dos-Reis Jordana Grazziela Alves, Teixeira-Carvalho Andréa, Martins-Filho Olindo Assis, Guimarães Gabriel Macedo Costa, Peruhype-Magalhães Vanessa

Abstract excerpt

Introduction: Mucosal-associated invariant T (MAIT) cells are unconventional T lymphocytes with innate-like antimicrobial responsiveness. Despite their recognized role in bacterial and viral infections, their involvement in protozoal diseases, particularly visceral leishmaniasis (VL) and HIV co-infection, remains poorly understood. Methods: A cross-sectional study evaluated the immunophenotypic profile of...

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