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Article

Expression of inhibitory receptors by B cells in chronic human infectious diseases restricts responses to membrane-associated antigens

24 Jul 2020

Abstract excerpt

Chronic human infectious diseases, including malaria, are associated with a large expansion of a phenotypically and transcriptionally distinct subpopulation of B cells distinguished by their high expression of a variety of inhibitory receptors including FcγRIIB. Because these B cells, termed atypical memory B cells (MBCs), are unable to respond to soluble antigens, it was suggested that they contributed to the...

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PMID: 32754637
DOI: 10.1126/sciadv.aba6493

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