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Article

Chronic Exposure to <i>Plasmodium falciparum</i> Is Associated with Phenotypic Evidence of B and T Cell Exhaustion

22 Dec 2012

Abstract excerpt

Naturally acquired immunity to malaria develops slowly, requiring several years of repeated exposure to be effective. The cellular and molecular factors underlying this observation are only partially understood. Recent studies suggest that chronic Plasmodium falciparum exposure may induce functional exhaustion of lymphocytes, potentially impeding optimal control of infection. However, it remains unclear whether...

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PMID: 23264654
DOI: 10.4049/jimmunol.1202438

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