Article

Blockade of LAG-3 in PD-L1-deficient mice enhances clearance of blood stage malaria independent of humoral responses

2020-06-22

Abstract excerpt

T cells expressing high levels of inhibitory receptors such as PD-1 and LAG-3 are a hallmark of chronic infections and cancer. Checkpoint blockade therapies targeting these receptors have been largely validated as promising strategies to restore exhausted T cell functions and clearance of chronic infections and tumors. The inability to develop long-term natural immunity in malaria-infected patients has been propos...

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Literature Corpus work: 1428e2d7-3d07-5bdf-abf6-d3a73e0a2e72
DOI: 10.1101/2020.06.22.164566

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