Article

Structures of vertebrate R2 retrotransposon complexes during target-primed reverse transcription and after second strand nicking

2024-11-12

Abstract excerpt

R2 retrotransposons are model site-specific eukaryotic non-LTR retrotransposons that copy-and-paste into gene loci encoding ribosomal RNAs. Recently we demonstrated that avian A-clade R2 proteins achieve efficient and precise insertion of transgenes into their native safe-harbor loci in human cells. The features of A-clade R2 proteins that support gene insertion are not characterized. Here, we report high resoluti...

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Literature Corpus work: 707edf09-8268-52fe-a84a-a4d4f66dac31
DOI: 10.1101/2024.11.11.623112

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