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Article

Identification of RNA binding motifs in the R2 retrotransposon-encoded reverse transcriptase.

Nucleic acids research - 1 Jul 2014

Jamburuthugoda Varuni K, Eickbush Thomas H

Abstract excerpt

R2 non-LTR retrotransposons insert at a specific site in the 28S rRNA genes of many animal phyla. R2 elements encode a single polypeptide with reverse transcriptase, endonuclease and nucleic acid binding domains. Integration involves separate cleavage of the two DNA strands at the target site and utilization of the released 3' ends to prime DNA synthesis. Critical to this integration is the ability of the protein...

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Identifiers

PMID: 24957604
DOI: 10.1093/nar/gku514
PMCID: PMC4117753

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