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A conserved viral RNA fold enables nuclease resistance across kingdoms of life

9 Aug 2025

Abstract excerpt

Viral exoribonuclease-resistant RNA (xrRNA) structures block cellular nucleases to produce subgenomic viral RNAs during infection. High sequence variability among xrRNAs from distantly related viruses raises questions about the shared molecular features that enable these RNAs to withstand the strong unwinding forces of exoribonucleases. Here, we present the first structure of a plant-virus xrRNA in its active...

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PMID: 40884403
DOI: 10.1093/nar/gkaf840

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