Article

Lineage-Specific Evolution, Structural Diversity, and Activity of R2 Retrotransposons in Animals

2025-05-09

Abstract excerpt

Retrotransposons play outsized roles in the evolution of gene regulation, genome function, and disease pathogenesis and more recently, have sparked interest as workhorses for new gene therapy approaches. R2 retrotransposons insert site-specifically to the multicopy genes encoding 28S ribosomal RNA at a target sequence conserved broadly across eukaryotic evolution. R2 retrotransposons have been detected in many ani...

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Literature Corpus work: 4cbdff29-7659-51f1-b0e2-1e11e316e063
DOI: 10.1101/2025.05.05.652312

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