Article

Whole-organism eQTL mapping at cellular resolution with single-cell sequencing

2020-08-24

Abstract excerpt

Genetic regulation of gene expression underlies variation in disease risk and other complex traits. The effect of expression quantitative trait loci (eQTLs) varies across cell types; however, the complexity of mammalian tissues makes studying cell-type eQTLs highly challenging. We developed a novel approach in the model nematode Caenorhabditis elegans that uses single cell RNA sequencing to map eQTLs at cellular...

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Literature Corpus work: 70716866-1d03-5d6b-8fec-8178d5c45e1e
DOI: 10.1101/2020.08.23.263798

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