iFORM/eQTL: an ultrahigh-dimensional platform for inferring the global genetic architecture of gene transcripts.

Abstract excerpt

Knowledge about how changes in gene expression are encoded by expression quantitative trait loci (eQTLs) is a key to construct the genotype-phenotype map for complex traits or diseases. Traditional eQTL mapping is to associate one transcript with a single marker at a time, thereby limiting our inference about a complete picture of the genetic architecture of gene expression. Here, we implemented an...

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