Article

The Mettl3 epitranscriptomic writer amplifies p53 stress responses

2021-10-21

Abstract excerpt

<h4>SUMMARY</h4> The p53 transcription factor, encoded by the most frequently mutated gene in human cancer, plays a critical role in tissue homeostasis in response to stress signals. The mechanisms through which p53 promotes downstream tumor suppressive gene expression programs remain, however, only superficially understood. Here, we used tandem affinity purification and mass spectrometry to reveal new components...

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Literature Corpus work: 70546cf9-8f5d-57ec-8c16-ccdee2db0179
DOI: 10.1101/2021.10.21.465324

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