Article

Helminth-remodeled microbial indole-3-lactic acid drives AhR-dependent disease tolerance

2026-05-08

Abstract excerpt

Helminths systemically suppress host immunity, yet whether they impose immune tolerance by rewiring host-associated microbial metabolism remains unclear. Here we show that Trichinella spiralis infection remodels intestinal tryptophan metabolism to generate an AhR-dependent regulatory immune state. T. spiralis infection enriched the commensal bacterium Ligilactobacillus murinus , which converted tryptophan into...

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Literature Corpus work: 7042605d-e895-500f-89ba-829f137a0b44
DOI: 10.64898/2026.05.06.723221

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