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Article

Microbiota control of a tryptophan–AhR pathway in disease tolerance to fungi

25 Sept 2014

Abstract excerpt

An increased understanding of the importance of microbiota in shaping the host's immune and metabolic activities has rendered fungal interactions with their hosts more complex than previously appreciated. The aryl hydrocarbon receptor (AhR) has a pivotal role in connecting tryptophan catabolism by microbial communities and the host's own pathway of tryptophan metabolite production with the orchestration of T-cell...

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PMID: 25256754
DOI: 10.1002/eji.201344406

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