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Gut Microbiota Modulation through Akkermansia spp . Supplementation Increases CAR T-cell Potency

11 Jun 2025

Abstract excerpt

This study investigates the clinical relevance of the gut microbiome at taxonomic and metabolic levels in anti-CD19 chimeric antigen receptor (CAR) T-cell therapy, both in patients and in a preclinical syngeneic tumor model. Patients with B-cell lymphoma treated with CD19 CAR T cells exhibited profound intestinal dysbiosis, exacerbated after CAR T-cell infusion. This dysbiosis was characterized by low bacterial...

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PMID: 40498998
DOI: 10.1158/2159-8290.cd-24-1230

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