Article

Genetic downregulation of interleukin-6 signaling and arteriolosclerotic cerebral small vessel disease: a drug target Mendelian randomization analysis

2024-12-14

Abstract excerpt

<h4>ABSTRACT</h4> <h4>Background</h4> Arteriolosclerotic cerebral small vessel disease (cSVD) is a leading cause of stroke and dementia, yet no disease-modifying therapies exist. Anti-inflammatory strategies targeting IL- 6 signaling have shown efficacy in preventing atherosclerotic cardiovascular disease, but their potential in arteriolosclerotic cSVD remains unexplored. We investigated whether genetically downre...

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Literature Corpus work: 702dc73c-2c09-5807-a140-93802abc08b2
DOI: 10.1101/2024.12.13.24318994

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