Optimizing treatment of cardiovascular risk factors in cerebral small vessel disease using genetics.

Abstract excerpt

Cerebral small vessel disease (cSVD) causes lacunar stroke (LS) and intracerebral haemorrhage and is the most common pathology underlying vascular dementia. However, there are few trials examining whether treatment of conventional cardiovascular risk factors reduces stroke risk in cSVD, as opposed to stroke as a whole. We used Mendelian randomization techniques to investigate which risk factors are causally...

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