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Article

Genetic Downregulation of Interleukin-6 Signaling and Arteriolosclerotic Cerebral Small Vessel Disease: A Drug Target Mendelian Randomization Analysis.

Journal of the American Heart Association - 4 Nov 2025

Tchuisseu-Kwangoua Larissa Ange, Omarov Murad, Shatunov Alexey, Markus Hugh S, Kamtchum-Tatuene Joseph, Georgakis Marios K

Abstract excerpt

BACKGROUND: Arteriolosclerotic cerebral small vessel disease (cSVD) is a leading cause of stroke and dementia, yet no disease-modifying therapies exist. Anti-inflammatory strategies targeting IL-6 (interleukin-6) signaling have shown efficacy in preventing atherosclerotic cardiovascular disease, but their potential in arteriolosclerotic cSVD remains unexplored. We investigated whether genetically downregulated...

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Identifiers

PMID: 41182006
DOI: 10.1161/JAHA.124.041814
PMCID: PMC12684786

Genes

IL6R

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