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Article

Circulating inflammatory cytokines and the risk of cerebral small vessel disease: a bidirectional Mendelian randomization analysis.

Journal of stroke and cerebrovascular diseases : the official journal of National Stroke Association - 1 Jan 2025

Han Shasha, Chen Qiong, Zhu Qiang, Han Wenxiu

Abstract excerpt

BACKGROUND: A correlation between inflammation and cerebral small vessel disease (CSVD) has been hypothesized by earlier observational research, while this correlation has not been well established. Considering the significant clinical value of this causality determination, Mendelian randomization (MR) was implemented to investigate the causality between inflammatory cytokines and CSVD radiological lesions....

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Cerebral Hemorrhage
Cerebral Small Vessel Diseases
Cytokines
Databases, Genetic
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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Fibroblast Growth Factors

Inflammation Mediators

Mendelian Randomization Analysis

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PMID: 39637729
DOI: 10.1016/j.jstrokecerebrovasdis.2024.108163

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