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Causal relationship between C-reactive protein and ischemic stroke caused by atherosclerosis: A Mendelian randomization study.

Journal of stroke and cerebrovascular diseases : the official journal of National Stroke Association - 1 Sept 2024

Yang Tao, Xie Weijie, Hu Fangwei, Cai Bin

Abstract excerpt

OBJECTIVES: This study investigates the association between C-reactive protein (CRP) and ischemic stroke caused by large artery atherosclerosis (LAA). METHODS: Five Mendelian Randomization (MR) methodologies were used for two-sample analyses: Inverse Variance Weighting (IVW), MR-Egger regression, Weighted Median (WM), Simple Mode, and Weighted Mode. CRP exposure data were obtained from aggregated summary...

Topics

Humans
Biomarkers
C-Reactive Protein
Genetic Predisposition to Disease
Genome-Wide Association Study
Intracranial Arteriosclerosis
Ischemic Stroke
Mendelian Randomization Analysis
Phenotype
Polymorphism, Single Nucleotide

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 39009197
DOI: 10.1016/j.jstrokecerebrovasdis.2024.107873

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