Article

A neuron-optimized CRISPR/dCas9 activation system for robust and specific gene regulation

2018-07-17

Abstract excerpt

Recent developments in CRISPR-based gene editing have provided new avenues to interrogate gene function. However, application of these tools in the central nervous system has been delayed due to difficulties in transgene expression in post-mitotic neurons. Here, we present a highly efficient, neuron-optimized dual lentiviral CRISPR-based transcriptional activation (CRISPRa) system to drive gene expression in prima...

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Literature Corpus work: 3501c857-e613-55e2-a7f7-10160a8884f2
DOI: 10.1101/371500

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