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Article

BDNF-DT and BDNF-AS-DT: novel genes in the BDNF locus.

Molecular psychiatry - 1 Oct 2026

Bach Svitlana V, Punzi Giovanna, Smith Nuri E, Mukherjee Sreya, Shin Joo Heon, Chen Qiang, Pertea Geo, Collado-Torres Leonardo, Maynard Kristen R, Page Stephanie C, Kleinman Joel E, Hyde Thomas M, Weinberger Daniel R, Martinowich Keri, Ursini Gianluca

Abstract excerpt

Divergent transcription from bidirectional promoters is frequently observed in eukaryotic genomes, but the biological relevance of divergent RNA transcripts (DT) is unknown. We identified and characterized BDNF-DT, a novel DT gene, and BDNF-AS-DT, a novel readthrough gene, in the locus containing BDNF, a gene with key roles in neuronal development, differentiation, and synaptic plasticity. BDNF-DT is independent...

Read the complete abstract on PubMed

Topics

Humans
Brain-Derived Neurotrophic Factor
Schizophrenia
Polymorphism, Single Nucleotide
Prefrontal Cortex

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Dorsolateral Prefrontal Cortex

RNA, Antisense

Male

Female

Neural Stem Cells

Neuronal Plasticity

Source

Open in PubMed Open full text

Identifiers

PMID: 42380610
DOI: 10.1038/s41380-026-03695-0
PMCID: PMC13569461

Genes

BDNF

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 24 Oct 2026.

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