Recursive mutational robustness in cancer through intra- and inter-genic compensation

Abstract excerpt

Mutational robustness is a fundamental property of biological systems allowing phenotypic stability against genotypic perturbation. At the gene level, this is primarily attributed to inter-genic functional redundancy driven by paralogs. Here, we show that intra-genic functional redundancy, driven by alternatively spliced isoforms, is another prevalent source of mutational robustness. Integrating isoform-resolved p...

Topics

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• Adaptation, Physiological
• Epigenesis, Genetic
• Gene Expression Regulation, Neoplastic
• Genetic Predisposition to Disease
• Genome
• Mutation
• Neoplasms
• Tumor Microenvironment

Identifiers and source

Literature Corpus work

7013ef02-0e6e-5ffd-be94-6749d39ae2dc

DOI

10.64898/2026.05.26.727768