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Article

A modular master regulator landscape controls cancer transcriptional identity.

Cell - 21 Jan 2021

Paull Evan O, Aytes Alvaro, Jones Sunny J, Subramaniam Prem S, Giorgi Federico M, Douglass Eugene F, Tagore Somnath, Chu Brennan, Vasciaveo Alessandro, Zheng Siyuan, Verhaak Roel, Abate-Shen Cory, Alvarez Mariano J, Califano Andrea

Abstract excerpt

Despite considerable efforts, the mechanisms linking genomic alterations to the transcriptional identity of cancer cells remain elusive. Integrative genomic analysis, using a network-based approach, identified 407 master regulator (MR) proteins responsible for canalizing the genetics of individual samples from 20 cohorts in The Cancer Genome Atlas (TCGA) into 112 transcriptionally distinct tumor subtypes. MR...

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Identifiers

PMID: 33434495
DOI: 10.1016/j.cell.2020.11.045
PMCID: PMC8103356

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