Article
Quantifying local malignant adaptation in tissue-specific evolutionary trajectories by harnessing cancer’s repeatability at the genetic level
2018-08-27
Abstract excerpt
Cancer is a potentially lethal disease, in which patients with nearly identical genetic backgrounds can develop a similar pathology through distinct combinations of genetic alterations. We aimed to reconstruct the evolutionary process underlying tumour initiation, using the combination of convergence and discrepancies observed across 2,742 cancer genomes from 9 tumour types. We developed a framework using the repe...
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Identifiers and source
- Literature Corpus work
- 5918bdbc-0475-55ad-ae33-a49f1bbbcccf
- DOI
- 10.1101/401059