The evolution of heterogeneities altered by mutational robustness, gene expression noise and bottlenecks in gene regulatory networks.

Abstract excerpt

Intra-population heterogeneity is commonly observed in natural and cellular populations and has profound influence on their evolution. For example, intra-tumor heterogeneity is prevalent in most tumor types and can result in the failure of tumor therapy. However, the evolutionary process of heterogeneity remains poorly characterized at both genotypic and phenotypic level. Here we study the evolution of...

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