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Strain-Specific Epistasis Shapes Fitness Landscapes of APOBEC3G Antagonism By HIV-1 Vif Proteins

2025-10-20

Abstract excerpt

Host immune factors shape viral evolution. The HIV-1 Vif protein counteracts host APOBEC3G (A3G) to ensure productive infection. Using deep mutational scanning (DMS) across two divergent HIV-1 Vif proteins, we systematically mapped and compared the mutational landscapes governing Vif antagonism of A3G. These high-resolution fitness maps reveal core principles of host–virus coevolution. Most missense mutations were...

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Literature Corpus work
03adfa36-4091-549e-a7d5-7208536f047b
DOI
10.1101/2025.10.20.683452
Open publication

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Strain-Specific Epistasis Shapes Fitness Landscapes of APOBEC3G Antagonism By HIV-1 Vif ProteinsDOI 10.1101/2025.10.20.683452
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