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Article

A single amino acid determinant governs the species-specific sensitivity of APOBEC3G to Vif action.

The Journal of biological chemistry - 9 Apr 2004

Mangeat Bastien, Turelli Priscilla, Liao Shunyao, Trono Didier

Abstract excerpt

APOBEC3G (also known as CEM15) is an innate intracellular antiretroviral factor that is counteracted by the Vif protein of lentiviruses. While APOBEC3G orthologues from several species are active against a broad range of retroviruses, given Vif proteins have a narrow spectrum of activity. For instance, HIV-1 Vif efficiently blocks APOBEC3G from human but not African green monkey (AGM), whereas the reverse is...

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Identifiers

PMID: 14966139
DOI: 10.1074/jbc.C400060200

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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A single amino acid determinant governs the species-specific sensitivity of APOBEC3G to Vif action.PMID 14966139Read ↗

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