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Identification of the HIV-1 Vif and Human APOBEC3G Protein Interface

25 Nov 2015

Abstract excerpt

Human cells express natural antiviral proteins, such as APOBEC3G (A3G), that potently restrict HIV replication. As a counter-defense, HIV encodes the accessory protein Vif, which binds A3G and mediates its proteasomal degradation. Our structural knowledge on how Vif and A3G interact is limited, because a co-structure is not available. We identified specific points of contact between Vif and A3G by using...

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PMID: 26628364
DOI: 10.1016/j.celrep.2015.10.068

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