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Genomic Landscape of GNAQ and GNA11 Mutations in Metastatic Solid Tumors: A Real-World Data Analysis.

JCO precision oncology - 1 Jul 2026

Kwon Minsuk, Go Yunjin, Shin Ji Eun, Lim Sung Hee, Hong Jung Yong, Park Se Hoon, Park Joon Oh, Park Young Suk, Jang Kee-Taek, Lee Jeeyun, Kim Seung Tae

Abstract excerpt

PURPOSE: Activating mutations in GNAQ and GNA11 are recognized oncogenic drivers in uveal melanoma (UM); however, their prevalence across various cancers and their genomic context remain inadequately characterized. This study aimed to elucidate the genomic landscape of these mutations across a range of metastatic solid tumors. MATERIALS AND METHODS: We conducted a pan-cancer analysis involving 5,416 patients with...

Topics

Humans
GTP-Binding Protein alpha Subunits, Gq-G11
Mutation
GTP-Binding Protein alpha Subunits
Neoplasms
Neoplasm Metastasis
Genomics
Female
Male

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Source

Open in PubMed Open full text

Identifiers

PMID: 42407004
DOI: 10.1200/PO-26-00072
PMCID: PMC13361959

Genes

GNA11
GNAQ
FAT1
NOTCH3
TP53

Variants

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 31 Aug 2026.

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