Article
Integrative Analysis Identifies Four Molecular and Clinical Subsets in Uveal Melanoma.
Cancer cell - 14 Aug 2017
Robertson A Gordon, Shih Juliann, Yau Christina, Gibb Ewan A, Oba Junna, Mungall Karen L, Hess Julian M, Uzunangelov Vladislav, Walter Vonn, Danilova Ludmila, Lichtenberg Tara M, Kucherlapati Melanie, Kimes Patrick K, Tang Ming, Penson Alexander, Babur Ozgun, Akbani Rehan, Bristow Christopher A, Hoadley Katherine A, Iype Lisa, Chang Matthew T, Cherniack Andrew D, Benz Christopher, Mills Gordon B, Verhaak Roel G W, Griewank Klaus G, Felau Ina, Zenklusen Jean C, Gershenwald Jeffrey E, Schoenfield Lynn, Lazar Alexander J, Abdel-Rahman Mohamed H, Roman-Roman Sergio, Stern Marc-Henri, Cebulla Colleen M, Williams Michelle D, Jager Martine J, Coupland Sarah E, Esmaeli Bita, Kandoth Cyriac, Woodman Scott E
Abstract excerpt
Comprehensive multiplatform analysis of 80 uveal melanomas (UM) identifies four molecularly distinct, clinically relevant subtypes: two associated with poor-prognosis monosomy 3 (M3) and two with better-prognosis disomy 3 (D3). We show that BAP1 loss follows M3 occurrence and correlates with a global DNA methylation state that is distinct from D3-UM. Poor-prognosis M3-UM divide into subsets with divergent genomic...
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