Multi-omics comparison of malignant and normal uveal melanocytes reveals novel molecular features of uveal melanoma

Abstract excerpt

Uveal Melanoma (UM) is a rare cancer resulting from transformation of melanocytes residing in the uveal tract. Integrative analysis has identified four molecular and clinical subsets in UM. To improve our molecular understanding of UM we performed extensive multi-omics characterization comparing two aggressive UM patient-derived xenograft models with normal choroidal melanocytes, including DNA optical mapping, spe...

Topics

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• GTP-Binding Protein alpha Subunits
• GTP-Binding Protein alpha Subunits, Gq-G11
• Melanoma, Cutaneous Malignant
• RNA Splicing Factors
• Tumor Suppressor p53-Binding Protein 1
• Ubiquitin Thiolesterase
• Uveal Melanoma
• Uveal Neoplasms

Identifiers and source

Literature Corpus work

7ee0f2e8-92cd-5db8-abea-c1835c8edc73

DOI

10.1101/2022.03.11.483767