Article

Neuro-glial lipid imbalance in a <i>Drosophila</i> model of Amyotrophic Lateral Sclerosis 8

2026-06-10

Abstract excerpt

Membrane Contact sites (MCS) have emerged as physiologically relevant zones that coordinate inter-organelle communication and cellular function. VAPB, an ER-resident MCS tethering protein, plays a central role in regulating MCSs through its numerous protein interactors, thereby influencing cellular homeostasis. A pathogenic missense VAPB P56S mutation causes familial Amyotrophic Lateral Sclerosis 8 (ALS8) in hum...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: 6fc83b99-4193-5510-b2b0-63cc0ce962e3
DOI: 10.64898/2026.06.06.730557

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Neuro-glial lipid imbalance in a <i>Drosophila</i> model of Amyotrophic Lateral Sclerosis 8DOI 10.64898/2026.06.06.730557Read

Age-dependent dynamics of neuronal VAPB <sup>ALS</sup> inclusions in the adult brainSemantic proximity Read

Increased levels of phosphoinositides cause neurodegeneration in a Drosophila model of amyotrophic lateral sclerosis.Semantic proximity Read

The Link between VAPB Loss of Function and Amyotrophic Lateral Sclerosis.Semantic proximity Read

SOD1 activity thresholds and TOR signalling modulate VAP(P58S) aggregation via ROS-induced proteasomal degradation in a <i>Drosophila</i> model of Amyotrophic Lateral SclerosisSemantic proximity Read

Fos regulates age-dependent neuroinflammation in <i> VAPB <sup>ALS</sup> </i>Semantic proximity Read

Age-dependent dynamics of neuronal VAPBALS inclusions in the adult brainSemantic proximity Read

Deregulation of phosphatidylinositol-4-phosphate in the development of amyotrophic lateral sclerosis 8.Semantic proximity Read

The amyotrophic lateral sclerosis 8 protein, VAP, is required for ER protein quality control.Semantic proximity Read

Mutant VAPB: Culprit or Innocent Bystander of Amyotrophic Lateral Sclerosis?Semantic proximity Read

Neurodegenerative and neurodevelopmental roles for bulk lipid transporters <i>VPS13A</i> and <i>BLTP2</i> in movement disordersSemantic proximity Read

A role for mitochondria-ER crosstalk in amyotrophic lateral sclerosis 8 pathogenesis.Semantic proximity Read

ALS-Linked VapB P56S Mutation Alters Neuronal Mitochondrial Turnover at the Synapse.Semantic proximity Read