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SOD1 activity thresholds and TOR signalling modulate VAP(P58S) aggregation via ROS-induced proteasomal degradation in a <i>Drosophila</i> model of Amyotrophic Lateral Sclerosis

2018-07-13

Abstract excerpt

Familial Amyotrophic Lateral Sclerosis (F-ALS) is an incurable, late onset motor neuron disease, linked strongly to various causative genetic loci. ALS8 codes for a missense mutation, P56S, in VAMP-associated Protein B (VAPB) that causes the protein to misfold and form cellular aggregates. Uncovering genes and mechanisms that affect aggregation dynamics would greatly help increase our understanding of the disease...

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Literature Corpus work
2e0c3e97-304d-5759-abf2-617d8a4a3ca1
DOI
10.1101/368100
Open publication

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