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Article

Deregulation of phosphatidylinositol-4-phosphate in the development of amyotrophic lateral sclerosis 8.

Advances in biological regulation - 1 Jan 2021

Wilson Cathal, Venditti Rossella, De Matteis Maria Antonietta

Abstract excerpt

Amyotrophic lateral sclerosis 8 (ALS8) is one of a heterogeneous group of progressive neurodegenerative disorders characterized by the death of motor neurons. ALS8 is caused by mutations in VAPB, a protein that acts at multiple membrane contact sites between the endoplasmic reticulum (ER) and almost all other organelles and thus affects functions at diverse cellular locations. One prominent function mediated by...

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Identifiers

PMID: 33461946
DOI: 10.1016/j.jbior.2020.100779

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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