Article

Age-dependent dynamics of neuronal VAPB <sup>ALS</sup> inclusions in the adult brain

2024-02-12

Abstract excerpt

<h4>ABSTRACT</h4> Amyotrophic Lateral Sclerosis (ALS) is a relentlessly progressive and fatal disease, caused by the degeneration of upper and lower motor neurons within the brain and spinal cord in the ageing human. The dying neurons contain cytoplasmic inclusions linked to the onset and progression of the disease. Here, we use a Drosophila model of ALS8 (VAP P58S ) to understand the modulation of these incl...

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Literature Corpus work: b564f64b-d31a-5b56-aeea-6d955d90fc5a
DOI: 10.1101/2024.02.12.579854

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