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Article

Age-dependent dynamics of neuronal VAPBALS inclusions in the adult brain

26 Apr 2024

Abstract excerpt

Amyotrophic Lateral Sclerosis (ALS) is a relentlessly progressive and fatal disease, caused by the degeneration of upper and lower motor neurons within the brain and spinal cord in the ageing human. The dying neurons contain cytoplasmic inclusions linked to the onset and progression of the disease. Here, we use a Drosophila model of ALS8 (VAPP58S) to understand the modulation of these inclusions in the ageing...

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PMID: 38679111
DOI: 10.1016/j.nbd.2024.106517

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