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Article

Increased levels of phosphoinositides cause neurodegeneration in a Drosophila model of amyotrophic lateral sclerosis.

Human molecular genetics - 1 Jul 2013

Forrest Stuart, Chai Andrea, Sanhueza Mario, Marescotti Manuela, Parry Katherine, Georgiev Atanas, Sahota Virender, Mendez-Castro Raquel, Pennetta Giuseppa

Abstract excerpt

The Vesicle-associated membrane protein (VAMP)-Associated Protein B (VAPB) is the causative gene of amyotrophic lateral sclerosis 8 (ALS8) in humans. Amyotrophic lateral sclerosis (ALS) is a progressive neurodegenerative disease characterized by selective death of motor neurons leading to spasticity, muscle atrophy and paralysis. VAP proteins have been implicated in various cellular processes, including...

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Source

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Identifiers

PMID: 23492670
DOI: 10.1093/hmg/ddt118
PMCID: PMC3674808

Genes

VAPB

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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