Article

Fos regulates age-dependent neuroinflammation in <i> VAPB <sup>ALS</sup> </i>

2026-03-03

Abstract excerpt

Amyotrophic Lateral Sclerosis (ALS) is a fatal neurodegenerative disorder characterized by progressive loss of motor function. We have developed a Drosophila model of ALS8 ( VAPB P58S ) using CRISPR/Cas9 genome editing. VAPB is an ER-based adapter protein associated with and regulating intracellular membrane:membrane contact sites. VAPB P58S flies show progressive age-dependent motor deficits and a shortened...

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Literature Corpus work: 05c5e70e-33f9-51ec-b8b5-dcbc58608120
DOI: 10.64898/2026.02.28.708780

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