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Article

The Link between VAPB Loss of Function and Amyotrophic Lateral Sclerosis.

Cells - 23 Jul 2021

Borgese Nica, Iacomino Nicola, Colombo Sara Francesca, Navone Francesca

Abstract excerpt

The VAP proteins are integral adaptor proteins of the endoplasmic reticulum (ER) membrane that recruit a myriad of interacting partners to the ER surface. Through these interactions, the VAPs mediate a large number of processes, notably the generation of membrane contact sites between the ER and essentially all other cellular membranes. In 2004, it was discovered that a mutation (p.P56S) in the VAPB paralogue...

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Identifiers

PMID: 34440634
DOI: 10.3390/cells10081865
PMCID: PMC8392409

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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The Link between VAPB Loss of Function and Amyotrophic Lateral Sclerosis.PMID 34440634Read ↗

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