Article

Dormancy, not apoptosis, restricts hematopoietic stem cell mutagenesis during aging

2026-05-13

Abstract excerpt

Genome instability and mutagenesis are hallmarks of aging, acting as drivers of some age-associated pathologies, including cancer 1–3 . Somatic cells engage multiple layers of protection against mutagenesis, including detoxification of genotoxic metabolites; repair of DNA damage; and elimination of cells which suffer excessive damage 4–7 . In this context, the intrinsic apoptotic pathway is engaged in response t...

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Literature Corpus work: 6fc31acb-5d97-57a3-bab1-45ddbe1f33ec
DOI: 10.64898/2026.05.09.724021

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