Article
Stem Cell-Specific Mechanisms Ensure Genomic Fidelity within HSCs and upon Aging of HSCs.
Cell reports - 22 Dec 2015
Moehrle Bettina M, Nattamai Kalpana, Brown Andreas, Florian Maria C, Ryan Marnie, Vogel Mona, Bliederhaeuser Corinna, Soller Karin, Prows Daniel R, Abdollahi Amir, Schleimer David, Walter Dagmar, Milsom Michael D, Stambrook Peter, Porteus Matthew, Geiger Hartmut
Abstract excerpt
Whether aged hematopoietic stem and progenitor cells (HSPCs) have impaired DNA damage repair is controversial. Using a combination of DNA mutation indicator assays, we observe a 2- to 3-fold increase in the number of DNA mutations in the hematopoietic system upon aging. Young and aged hematopoietic stem cells (HSCs) and hematopoietic progenitor cells (HPCs) do not show an increase in mutation upon...
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