Article

Proliferative events ameliorate DNA damage accumulation without affecting function in hematopoietic stem cells

2024-08-21

Abstract excerpt

Upon aging, HSCs show functional decline with increased proliferation, myeloid skewing, and poor engraftment efficiency. Accumulation of DNA damage has been causally linked with this phenomenon, with the debatable role of proliferative events. In this study, we sought to enquire the effect of increased hematopoietic stem cell (HSC) proliferation during the lifetime on the hematopoietic aging in mice. Multiple roun...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: 5e3a72aa-b1fd-56a6-b4b4-c6d893cf63c7
DOI: 10.1101/2024.08.21.608631

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Proliferative events ameliorate DNA damage accumulation without affecting function in hematopoietic stem cellsDOI 10.1101/2024.08.21.608631Read

Quiescent hematopoietic stem cells accumulate DNA damage during aging that is repaired upon entry into cell cycle.Semantic proximity Read

Concise Review: Hematopoietic Stem Cell Aging and the Prospects for RejuvenationSemantic proximity Read

Cellular and Molecular Mechanisms Involved in Hematopoietic Stem Cell Aging as a Clinical ProspectSemantic proximity Read

Understanding intrinsic hematopoietic stem cell agingSemantic proximity Read

Aging of hematopoietic stem cells: DNA damage and mutations?Semantic proximity Read

Molecular and phenotypic blueprint of the hematopoietic compartment reveals proliferation stress as a driver of age-associated human stem cell dysfunctionsSemantic proximity Read

Molecular and phenotypic blueprint of human hematopoiesis links proliferation stress to stem cell aging.Semantic proximity Read

Mechanisms and rejuvenation strategies for aged hematopoietic stem cellsSemantic proximity Read

DNA damage and repair in the hematopoietic systemSemantic proximity Read

Reconsidering the usual suspects in age-related hematologic disorders: is stem cell dysfunction a root cause of aging?Semantic proximity Read

DNA methylation drives hematopoietic stem cell aging phenotypes after proliferative stress.Semantic proximity Read

Causes and Mechanisms of Hematopoietic Stem Cell AgingSemantic proximity Read