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KANK2 at focal adhesion regulates their maintenance and dynamics, while at fibrillar adhesions it influences cell migration via microtubule-dependent mechanism

2025-02-26

Abstract excerpt

<h4>ABSTRACT</h4> <h4>Background</h4> Integrins form focal adhesions (FAs) at the cell edge and fibrillar adhesions (FBs) located centrally. Talin 1 is essential to FAs, while talin2 is found in FAs and FBs. KANK (kidney ankyrin repeat-containing) family proteins regulate adhesion dynamics and are recruited to adhesions through interaction with talins. Previously, we showed in MDA-MB-435S melanoma cells that KAN...

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Literature Corpus work
6f9c688a-9439-51eb-be92-5c8a7449ba34
DOI
10.1101/2025.02.24.639831
Open publication

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