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Article

Focal adhesion complex proteins in epidermis and squamous cell carcinoma

3 Oct 2013

Abstract excerpt

Focal adhesions (FAs) are large, integrin-containing, multi-protein assemblies spanning the plasma membrane that link the cellular cytoskeleton to surrounding extracellular matrix. They play critical roles in adhesion and cell signaling and are major regulators of epithelial homeostasis, tissue response to injury, and tumorigenesis. Most integrin subunits and their associated FA proteins are expressed in skin,...

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PMID: 24036537
DOI: 10.4161/cc.26385

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