Article

Talin2 and KANK2 functionally interact to regulate microtubule dynamics, paclitaxel sensitivity and cell migration in the MDA-MB-435S melanoma cell line

2023-04-14

Abstract excerpt

<title>Abstract</title><p><bold>Background</bold>Focal adhesions (FAs) are integrin-containing, multi-protein structures that link intracellular actin to the extracellular matrix and trigger multiple signaling pathways that control cell proliferation, differentiation, survival and motility. Microtubules (MTs) are stabilized in the vicinity of FAs through interaction with the components of the cortical microtubule...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: 683d9409-0ad6-5ef3-997e-15d9d73b6d28
DOI: 10.21203/rs.3.rs-2742334/v1

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Talin2 and KANK2 functionally interact to regulate microtubule dynamics, paclitaxel sensitivity and cell migration in the MDA-MB-435S melanoma cell lineDOI 10.21203/rs.3.rs-2742334/v1Read

Talin2 and KANK2 functionally interact to regulate microtubule dynamics, paclitaxel sensitivity and cell migration in the MDA-MB-435S melanoma cell lineSemantic proximity Read

KANK2 at focal adhesion regulates their maintenance and dynamics, while at fibrillar adhesions it influences cell migration via microtubule-dependent mechanismSemantic proximity Read

Thymosin β4 Regulates Focal Adhesion Formation in Human Melanoma Cells and Affects Their Migration and InvasionSemantic proximity Read

The role of talin2 in breast cancer tumorigenesis and metastasisSemantic proximity Read

Tetraspanin 8 is a novel regulator of ILK-driven β1 integrin adhesion and signaling in invasive melanoma cells.Semantic proximity Read

Molecular aspects of tumor cell migration and invasion.Semantic proximity Read

The role of Tks adaptor proteins in invadopodia formation, growth and metastasis of melanomaSemantic proximity Read

A cryptic tubulin-binding domain links MEKK1 to microtubule remodellingSemantic proximity Read

Regulation of Cell Adhesion and Migration via Microtubule Cytoskeleton Organization, Cell Polarity, and Phosphoinositide SignalingSemantic proximity Read

The complexity of integrins in cancer and new scopes for therapeutic targetingSemantic proximity Read

RacGAP1-driven focal adhesion formation promotes melanoma transendothelial migration through mediating adherens junction disassembly.Semantic proximity Read

RNAi screen identifies KIF15 as a novel regulator of integrin endocytic traffickingSemantic proximity Read