Article
Tetraspanin 8 is a novel regulator of ILK-driven β1 integrin adhesion and signaling in invasive melanoma cells.
Oncotarget - 7 Mar 2017
El Kharbili Manale, Robert Clément, Witkowski Tiffany, Danty-Berger Emmanuelle, Barbollat-Boutrand Laetitia, Masse Ingrid, Gadot Nicolas, de la Fouchardière Arnaud, McDonald Paul C, Dedhar Shoukat, Le Naour François, Degoul Françoise, Berthier-Vergnes Odile
Abstract excerpt
Melanoma is well known for its propensity for lethal metastasis and resistance to most current therapies. Tumor progression and drug resistance depend to a large extent on the interplay between tumor cells and the surrounding matrix. We previously identified Tetraspanin 8 (Tspan8) as a critical mediator of melanoma invasion, whose expression is absent in healthy skin. The present study investigated whether Tspan8...
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