Article
Parkinson's disease-linked mutations in VPS35 induce dopaminergic neurodegeneration.
Human molecular genetics - 1 Sept 2014
Tsika Elpida, Glauser Liliane, Moser Roger, Fiser Aris, Daniel Guillaume, Sheerin Una-Marie, Lees Andrew, Troncoso Juan C, Lewis Patrick A, Bandopadhyay Rina, Schneider Bernard L, Moore Darren J
Abstract excerpt
Mutations in the vacuolar protein sorting 35 homolog (VPS35) gene at the PARK17 locus, encoding a key component of the retromer complex, were recently identified as a new cause of late-onset, autosomal dominant Parkinson's disease (PD). Here we explore the pathogenic consequences of PD-associated mutations in VPS35 using a number of model systems. VPS35 exhibits a broad neuronal distribution throughout the rodent...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.