Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Role of the VPS35 D620N mutation in Parkinson's disease.

Parkinsonism & related disorders - 1 Mar 2017

Mohan Megha, Mellick George D

Abstract excerpt

Parkinson's disease (PD) is a neurodegenerative disorder involving the loss of dopaminergic neurons in the brain. Following the discovery of the PD-causing D620N mutation in the VPS35 (Vacuolar sorting protein 35) gene, dysfunction in the subcellular retromer complex has been strongly implicated in pathogenesis of PD. Although the function and dysfunction of the retromer has been a focus of study for some time,...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Cellular transport and secretion
Share to VPS35 gene
Share to Mutation

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Share to Parkinson Disease

Share to Parkinson's Disease Mechanisms and Treatments

Share to RNA regulation and disease

Share to Vesicular Transport Proteins

Source

Identifiers

PMID: 27964832
DOI: 10.1016/j.parkreldis.2016.12.001

Genes

VPS35

Variants

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence. Graph snapshot: 2026-09-29.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Role of the VPS35 D620N mutation in Parkinson's disease.PMID 27964832Read ↗

VPS35 and retromer dysfunction in Parkinson's disease.Semantic proximity Read ↗

An update on cellular and molecular determinants of Parkinson's disease with emphasis on the role of the retromer complex.Semantic proximity Read ↗

VPS35, the Retromer Complex and Parkinson's Disease.Semantic proximity Read ↗

Understanding the contributions of VPS35 and the retromer in neurodegenerative disease.Semantic proximity Read ↗

The VPS35 protein and the role of its impairments in mitochondrial dysfunction in Parkinson's disease.Semantic proximity Read ↗

VPS35, the core component of the retromer complex, and Parkinson's diseaseSemantic proximity Read ↗

VPS35 and the mitochondria: Connecting the dots in Parkinson's disease pathophysiologySemantic proximity Read ↗

Retromer's Role in Endosomal Trafficking and Impaired Function in Neurodegenerative Diseases.Semantic proximity Read ↗

Endosomal dysfunction in iPSC-derived neural cells from Parkinson's disease patients with VPS35 D620N.Semantic proximity Read ↗

Endosomal Dysfunction in iPSC-Derived Neural Cells from Parkinson’s Disease Patients with VPS35 D620NSemantic proximity Read ↗

VPS35 mutations in Parkinson disease.Semantic proximity Read ↗

VPS35 dysfunction impairs lysosomal degradation of α-synuclein and exacerbates neurotoxicity in a Drosophila model of Parkinson's disease.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.